TaRGETed Therapy with Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy (TaRGET).

About the Study

The TaRGET trial is a multi-centre, prospective, randomized, double-blind, placebo-controlled trial designed to evaluate the potential therapeutic efficacy of tideglusib, a glycogen synthase kinase-3 beta (GSK3β) inhibitor, in genotype positive arrhythmogenic cardiomyopathy (ACM). In this trial ‘genotype positive’ refers to a pathogenic or likely pathogenic desmosomal (PKP2, DSG2, DSC2, DSP, or JUP*) rare variant OR the TMEM43-p.S358L variant.

To learn more about the study and it’s background information you may click here →

Important Definitions

Multi-Centre: This term means that the study is being carried out at multiple hospitals or clinics.

Prospective: A prospective trial is one in which participants are followed over time to see how the treatment affects them. This means the study looks forward, from the point of enrollment into the future, to gather data.

Randomized: In a randomized trial, participants are randomly assigned to either the treatment group or the control group. This process helps ensure that the study is fair and that the results are not influenced by any outside factors.

Double-blind: Double-blind means that neither the participants in the study nor the researchers know who is receiving the real treatment and who is receiving the placebo. This helps prevent biases in interpreting the results.

Placebo-controlled: A placebo-controlled trial includes a group of participants who receive a placebo, an inactive substance that looks like the treatment but has no therapeutic effect. Comparing the results of the treatment group to the placebo group helps researchers understand the treatment’s actual effect.

Pathogenic: A change in the DNA sequence of a gene that causes a person to have or be at risk of developing a certain genetic disorder or disease.

You can also learn more about the TaRGET trial by watching our SADS Expert Insights webinar featuring principal investigator of the TaRGET Trial, Dr. Jason Roberts.

Enrollment Information

If you think you may be eligible to participate in this clinical trial or you have any questions, please contact your local participating site or the central trial office at: TaRGET.Recruitment@phri.ca

You may also contact The Canadian SADS Foundation at any time at info@sads.ca for additional information about this this important clinical trial.

“Your participation in research is your gift to future generations!”

Participating Canadian Sites

See the list of participating clinics below: